| Characteristic |
Type 1 |
Type 2 |
Monogenic |
| Genetics |
Polygenic |
Polygenic |
Monogenic |
| Age of onset |
6 months to young adulthood |
Usually pubertal (or later)
|
Often post pubertal except Glucokinase and neonatal diabetes |
| Clinical presentation |
Most often acute, rapid
|
Variable; from slow, mild (often insidious) to severe |
Variable (may be incidental in glucokinase) |
Associations
Autoimmunity
Ketosis |
Yes
Common
|
No
Uncommon
|
No
Common in neonatal diabetes, rare in other forms |
| Obesity |
Population |
Increased frequency |
Population frequency |
Acanthosis nigricans
Frequency
(% of all diabetes
in young people)
Parent with diabetes |
No
Usually 90%+
2-4% |
Yes
Most countries
80% |
No
1-3%
90% |
