Figure 1: Urinary protein excretion (A), TBARs excretion (B) and renal ICAM- 1 expression levels relative to β-actin (C) in WT and 12/15-LO deficient mice after 10 weeks of induction of diabetes with streptozotocin. Diabetic WT mice displayed significant elevations in proteinuria, TBARs excretion and renal ICAM-1 expression compared to control. 12/15-LO deficiency prevented the elevation in proteinuria, TBARs excretion and renal ICAM-1 during diabetes. (*P<0.05 vs. control WT mice, #P<0.05 vs. diabetic WT mice and λP <0.05 vs. control 12/15-LO deficient mice, n=6-8/group for excretion data and n=4 for ICAM-1 expression).