Figure 2: Renal 12-LO expression relative to β-actin (A) and renal 12-HETE levels in control and diabetic WT mice with or without baicalein treatment for 4 and 10 weeks. Renal 12-LO expression and 12-HETE levels increased significantly in diabetic versus control mice. Inhibition of 12/15-LO with baicalein treatment resulted in significant reduction in 12-LO expression and 12-HETE levels either after 4 or 10 weeks ((*P<0.05 vs. control and #P<0.05 vs. diabetic mice, n=6/group).