Figure 7: A. Renal CYP4A hydroylase (A), CYP2J epoxygenase (B) and soluble epoxide hydrolase (sEH, C) expression levels relative to β-actin in WT with or without baicalein treatment and 12/15-LO deficient mice after 24 hours of injection with LPS. Renal CYP4A hydroxylase was significantly elevated in LPS injected WT mice versus control and was reduced in LPS injected 12/15-LO deficient mice. Although there was no difference in renal CYP2J epoxygenase among mice group, renal sEH increased in LPS injected WT mice. Baicalein treatment or 12/15-LO deficiency reduced the elevation in renal sEH expression in LPS injected WT mice (*P <0.05 vs. control mice, #P <0.05 vs. LPS injected WT mice, and λP <0.05 vs. control 12/15-LO deficient mice, n=4/group).