ZL ZL + LA ZDF ZDF + LA
Final body weight (g) 312 ± 6 305 ± 6 365 ± 9 ** 326 ± 5 ++
Plasma glucose (mmol/L) 5.8 ± 0.4 5.3 ± 0.3 16.8 ± 1.8** 12.9 ± 1.7**
  Plasma insulin (pmol/L) 471.5 ± 36.5 520.6 ± 130.2 2098.9 ± 313.5** 2087.0 ± 253.9**
HOMA index 18.0 ± 1.9 17.5 ± 4.3 271.9 ± 30.9** 182.4 ± 50.9**
Data are means ± SEM obtained from 8 rats in each group. ** P < 0.01 vs ZL rats, ++ P < 0.01 vs ZDF rats.
Intra-assay coefficient of variance for glucose and insulin in each group are: ZL (19.51, 21.90), ZL + LA (16.01, 70.74), ZDF (30.30, 42.52) and ZDF + LA (37.27, 34.29), respectively.
Table 2: Effect of 6-week treatment with α-lipoic acid (LA) on basal metabolic parameters in 12 weeks old Obese Zucker diabetic fatty (ZDF) rats and agematched Zucker lean (ZL) rats.