| |
|
ZL |
ZL + LA |
ZDF |
ZDF + LA |
| Final body weight (g) |
312 |
± |
6 |
305 |
± |
6 |
365 |
± |
9 ** |
326 |
± |
5 ++ |
| Plasma glucose (mmol/L) |
5.8 |
± |
0.4 |
5.3 |
± |
0.3 |
16.8 |
± |
1.8** |
12.9 |
± |
1.7** |
|
Plasma insulin (pmol/L) |
471.5 |
± |
36.5 |
520.6 |
± |
130.2 |
2098.9 |
± |
313.5** |
2087.0 |
± |
253.9** |
| HOMA index |
18.0 |
± |
1.9 |
17.5 |
± |
4.3 |
271.9 |
± |
30.9** |
182.4 |
± |
50.9** |
|
| Data are means ± SEM obtained from 8 rats in each group. ** P < 0.01 vs ZL rats,
++ P < 0.01 vs ZDF rats. |
| Intra-assay coefficient of variance for glucose and insulin in each group are: ZL
(19.51, 21.90), ZL + LA (16.01, 70.74), ZDF (30.30, 42.52) and ZDF + LA (37.27,
34.29), respectively. |
| Table 2: Effect of 6-week treatment with α-lipoic acid (LA) on basal metabolic
parameters in 12 weeks old Obese Zucker diabetic fatty (ZDF) rats and agematched
Zucker lean (ZL) rats. |
