DQA1 Siblings
n=54(%)
Controls
n= 50(%)
X2 P Values OR 95% CI
*01:01 6(11.1) 2(4) 0.98 0.32 3.0 0.6-13.5
*01:02 18 (33.3) 13 (26) 0.36 0.54 1.4 0.62-3.2
*01:03 3 (5.6) 8 (16) 1.99 0.16 0.31 0.08-1.15
*01:05 1(1.8) 2(4) 0.005 0.95 0.45 0.05-3.59
*02:01 3(5.6) 27(54) 27.37 0.0001 0.05 0.2-0.17
*03:01 9 (16.7) 12 (24) 0.47 0.45 0.63 0.24-1.6
*03:03 18 (33.3) 3 (6) 10.40 0.001 7.83 1.96-36.44
*04:01 3 (5.6) 1(2) 0.19 0.66 2.88 0.39-20.7
*05:01 33 (61.1) 13 (26) 11.59 0.001 4.47 1.95-10.24
*05:05 3 (5.6) 7 (14) 11.75 0.001 0.11 0.03-0.39
DQB1            
*02:01 39 (72.2) 15(30) 16.8 0.0001 6.06 2.6-14.08
*03:01(7) 3(5.6) 13 (26) 6.83 0.009 0.16 0.05-0.59
*03:02 (8) 12 (22.2) 10 (20) 0.001 0.971 1.14 0.45-2.88
*04:02 9 (16.7) 5 (10) 0.51 0.47 1.8 0.58-5.5
*05:01 6(11.1) 18 (36) 7.7 0.005 0.22 0.08-0.62
*06:02 21 (38.9) 23 (46) 0.28 0.59 0.74 0.34-1.62
DQB1*02:01/
DQB1*02:01
18(33.3) 6(12) 5.51 0.019 3.67 1.2-11.65
             
DRB1*03:01-DQA1*05:01-DQB1*02:01 33 (61) 13(26.7) 11.6 0.001 4.47 1.9-10.2
X2 = chi square; OR = odds ratio; CI = confidence interval; *statistically significant
Table 2: The frequency of HLA-DQA1, DQB1 haplotype among siblings of T1DM and controls.