Probe Set ID Symbol Gene Name 10412218 Gzmk Granzyme K 10432652 Cela1 Chymotrypsin-like elastase family member 1 10449467 Clps Colipase, Pancreatic 10464313 Pnliprp1 Pancreatic Lipase-related Protein 1 10497831 Ccna2 Cyclin A2 10518050 Cela2a Chymotrypsin-like elastase family member 2A 10518059 Ctrc Chymotrypsin C (Caldecrin) 10524698 Pla2g1b Phospholipase A2, Group 1B 10537638 Try10 Trypsin 10 10537650 Prss1 Protease, Serine, 1 (Trypsin 1) 10544333 Try5 Trypsin 5

Table 1: List of differentially expressed genes in pancreatic Tregs: Genes (n=11) were selected from the heat map if they possessed a fold-change > 2 in pancreatic Tregs and ≤ 0 in other Treg populations.