| Gene |
Primary Function |
Link to Tregs? |
Link to Diabetes? |
| Gzmk[14,16] |
Induces macrophages to secrete IL-1β (pro-inflammatory |
IL-1β facilitates conversion of Tregs to Tregs to IL-17 cells |
No |
| Cela1 [16] |
Necessary for differentiation of pancreatic exocrine cells |
No |
Signaled downstream of Nkx2.2; Nkx2.2 mutation Nkx2.2; Nkx2.2 mutation death |
| Clps[19-23] |
Necessary for efficient dietary lipid & triglyceride hydrolysis |
Mutations→Fatty Acid disruptions |
Mutations→increased T2D susceptibility |
| Pnliprp1 [21] |
Necessary for efficient triglyceride hydrolysis |
Mutations→Fatty Acid disruptions |
Knock-out→increased weight gain & severe insulin resistance (T2D) |
| Cela2 [16] |
Linked to pancreatic proelastase II enzyme activity |
No |
No |
| Ctrc[14,16] |
Linked to trypsinogen activation |
Trypsinogen hydrolyzes proteins, may play role in Treg function |
No |
| Pla2g1b [19-21] |
Necessary for efficient lipid hydrolysis & fat absorption |
Mutations→Fatty Acid disruptions can cause Treg membrane alterations & result in cell death |
Pla2g1b -/- mice are protected from insulin are protected from insulin obesity |
| Prss1 [14] |
Linked to trypsinogen activation |
alterations & result in cell death hydrolyzes proteins, may play role in Treg function |
No |
