| |
Lou/C |
Wistar |
Anova |
| Systolic pressure (mmHg) |
135 ± 3 |
139 ± 5 |
NS |
| Diastolic pressure (mmHg) |
12 ± 0.5 |
12 ± 0.9 |
NS |
| LVDP (mmHg) |
123 ± 3 |
127 ± 5 |
NS |
| Heart rate (beats/min) |
311 ± 9 |
271 ± 8 |
p < 0.01 |
| Rate pressure product (mHg/min) |
38 ± 1 |
34 ± 1 |
p < 0.05 |
| Coronary flow (ml/min/g) |
8.3 ± 0.8 |
6.6 ± 0.3 |
p < 0.05 |
| Oxygen consumpt. (µmoles/min/g) |
4.9 ± 0.4 |
4.1 ± 0.2 |
NS |
| Metabolic efficiency (mHg/µmole) |
7.3 ± 0.5 |
5.4 ± 0.2 |
p < 0.01 |
| Lactate release (µmoles/min/g) |
0.33 ± 0.02 |
0.47 ± 0.04 |
p < 0.01 |
| Pyruvate release (µmoles/min/g) |
0.028 ± 0.004 |
0.034 ± 0.004 |
NS |
| Glycolytic flux (µmoles/min/g) |
0,37 ± 0.02 |
0.51 ± 0.04 |
p < 0.01 |
| Lactate to pyruvate ratio |
16 ± 3 |
16 ± 3 |
NS |
| Ratio between released lactate and consumed oxygen (µmoles/µmole) |
0.075 ± 0.009 |
0.119 ± 0.011 |
p < 0.01 |
| The number of experiments was 10 per group. LVDP: left ventricle developed pressure; Oxygen consumpt.: oxygen consumption; g: gram of heart weight; Anova: analysis of variance; NS: not significant. |
