Lou/C Wistar Anova
Systolic pressure (mmHg) 135 ± 3 139 ± 5 NS
Diastolic pressure (mmHg) 12 ± 0.5 12 ± 0.9 NS
LVDP (mmHg) 123 ± 3 127 ± 5 NS
Heart rate (beats/min) 311 ± 9 271 ± 8 p < 0.01
Rate pressure product (mHg/min) 38 ± 1 34 ± 1 p < 0.05
Coronary flow (ml/min/g) 8.3 ± 0.8 6.6 ± 0.3 p < 0.05
Oxygen consumpt. (µmoles/min/g) 4.9 ± 0.4 4.1 ± 0.2 NS
Metabolic efficiency (mHg/µmole) 7.3 ± 0.5 5.4 ± 0.2 p < 0.01
Lactate release (µmoles/min/g) 0.33 ± 0.02 0.47 ± 0.04 p < 0.01
Pyruvate release (µmoles/min/g) 0.028 ± 0.004 0.034 ± 0.004 NS
Glycolytic flux (µmoles/min/g) 0,37 ± 0.02 0.51 ± 0.04 p < 0.01
Lactate to pyruvate ratio 16 ± 3 16 ± 3 NS
Ratio between released lactate and consumed oxygen (µmoles/µmole) 0.075 ± 0.009 0.119 ± 0.011 p < 0.01
The number of experiments was 10 per group. LVDP: left ventricle developed pressure; Oxygen consumpt.: oxygen consumption; g: gram of heart weight; Anova: analysis of variance; NS: not significant.
Table 1: Ex- vivo cardiac function of Lou/C and Wistar rats under pre-ischemic conditions.