| Author & year |
Design/Methods |
Results/Conclusion |
| Balducci et al. [50] |
-Randomized controlled clinical trial
-4 year (4h/week) exercise program in diabetes patients without neuropathy at enrollment |
-Significantly more cases of sensory or motor neuropathy in the control group during the 4 years
-Exercise may delay or even prevent the onset of DPN in diabetic patients |
| Smith et al. [51] |
-Individualized diet and exercise counseling in patients with neuropathy associated with impaired glucose tolerance (IGT) for 1 year |
-Positive changes in intraepidermal nerve fiber density (IENFD) and reductions in pain in the visual analog scale (VAS)
- IENFD should be included as an end point in future neuropathy trials. |
| Chen et al. [17] |
-Randomized controlled trial with rodent model
-Daily exercise training in induced diabetic mice vs sedentary induced diabetic mice |
-Reductions in diabetes-associated neuropathic pain, including thermal hyperalgesia and mechanical allodynia in the exercise group
-Greater expression of Hsp72 in the exercise group |
| Kluding et al. [53] |
-10-week exercise and resistance training program in DPN patients |
-Increases in IENF branching, reductions in pain (VAS), reductions in neuropathic symptoms post exercise program |
