| Characteristic |
Patient 1 |
Patient 2 |
| Age of onset |
Pubertal period |
After puberty |
| Clinical presentation |
Rapid |
Slow |
| Autoimmunity |
Weakly positive |
Positive |
| Ketonuria |
++ |
+ |
| Glycemia |
High |
High |
| Obesity |
Yes |
Yes |
| Acanthosis nigricans |
No |
Yes |
| Additional autoimmune disease |
No |
Yes |
| Diagnosis of diabetes on routine physical examination |
No |
Yes |
| T2D in family history |
Yes |
No |
| HTN in family history |
Yes |
Yes |
| Obesity in family history |
No |
Yes |
| Autoimmune disease in family history |
No |
No |
(Highlighted features characteristic for T2DM)
This table shows how blurred the initial diagnosis of DM in such patients can be. Despite presence of obesity, rapidly developing symptoms accompanied by hyperglycemia
and elevated A1C seen in our male patient suggested T1DM diagnosis. On the other hand, the girl presented the typical clinical phenotype of T2DM with features of insulin
resistance (obesity, acanthosis nigricans) and slow clinical presentation,but also with high titers of islet autoantibodies |
