| Characteristic |
Responder |
Non-responder |
P value |
| No. of subjects |
35 |
(72.9) |
13 |
(27.1) |
|
| Male |
15 |
(42.9) |
6 |
(46.2) |
0.838 |
| Age (year) |
60.4 |
(12.4) |
57.4 |
(10.1) |
0.441 |
| Body mass index (kg/m2) |
25.01 |
(3.72) |
26.24 |
(3.56) |
0.344 |
| Duration of diabetes (year) |
7.54 |
(5.17) |
8.85 |
(4.96) |
0.437 |
| Baseline |
|
|
|
|
|
| FPG (mmol/L) |
6.79 |
(1.05) |
6.80 |
(0.79) |
0.980 |
| 2-hour PPG (mmol/L) |
10.73 |
(2.84) |
11.03 |
(2.04) |
0.737 |
| HbA1c (%) |
7.25 |
(0.40) |
7.00 |
(0.42) |
0.059 |
| Fasting plasma insulin (pmol/L) |
90.42 |
(79.03) |
48.27 |
(17.15) |
0.214 |
| Blood urea nitrogen (mmol/L) |
5.22 |
(1.25) |
4.97 |
(1.66) |
0.568 |
| Creatinine (μmol/L) |
72.49 |
(13.26) |
81.33 |
(15.91) |
0.065 |
| eGFR (mL/min/1.73m2) |
89.94 |
(15.27) |
82.50 |
(15.93) |
0.156 |
| Aspartate aminotransferase (IU/L) |
20.34 |
(10.87) |
22.62 |
(7.47) |
0.492 |
| Alanine aminotransferase (IU/L) |
24.00 |
(18.69) |
24.85 |
(12.32) |
0.881 |
| Total cholesterol (mmol/L) |
4.47 |
(0.76) |
4.51 |
(0.89) |
0.902 |
| HDL cholesterol (mmol/L) |
1.23 |
(0.27) |
1.21 |
(0.26) |
0.819 |
| LDL cholesterol (mmol/L) |
2.59 |
(0.68) |
2.51 |
(0.82) |
0.759 |
| Triglyceride (mmol/L) |
1.41 |
(0.59) |
1.78 |
(0.50) |
0.056 |
| HOMA-B |
105.52 |
(141.48) |
46.77 |
(23.61) |
0.329 |
| HOMA-IR |
3.60 |
(2.70) |
2.06 |
(0.66) |
0.185 |
| Dose of daily metformin (mg) |
945.71 |
(392.65) |
976.92 |
(454.89) |
0.816 |
| Dose of daily vildagliptin (mg) |
87.14 |
(22.17) |
84.62 |
(24.02) |
0.733 |
| 3 month after Vildagliptin administration |
|
|
|
|
|
| FPG (mmol/L) |
6.06 |
(1.00) |
7.42 |
(1.29) |
<0.001 |
| ΔFPG (mmol/L) |
-0.73 |
(0.92) |
0.62 |
(1.13) |
<0.001 |
| 2-hour PPG (mmol/L) |
8.34 |
(2.28) |
10.08 |
(2.81) |
0.035 |
| Δ2-hour PPG (mmol/L) |
-2.43 |
(2.89) |
-1.40 |
(1.40) |
0.117 |
| HbA1c (%) |
6.26 |
(0.44) |
6.87 |
(0.59) |
<0.001 |
| ΔHbA1c (%) |
-0.99 |
(0.32) |
-0.13 |
(0.51) |
<0.001 |
| 6 month after Vildagliptin administration |
|
|
|
|
|
| FPG (mmol/L) |
6.24 |
(1.00) |
6.89 |
(1.29) |
0.098 |
| ΔFPG (mmol/L) |
-0.59 |
(0.90) |
0.10 |
(0.81) |
0.024 |
| 2-hour PPG (mmol/L) |
8.66 |
(2.28) |
10.63 |
(2.81) |
0.024 |
| Δ2-hour PPG (mmol/L) |
-2.07 |
(2.65) |
-0.39 |
(2.71) |
0.074 |
| HbA1c (%) |
6.28 |
(0.32) |
6.80 |
(0.68) |
0.003 |
| ΔHbA1c (%) |
-0.97 |
(0.42) |
-0.20 |
(0.41) |
<0.001 |
Results expressed as n (%) or mean values (SD). Chi-square test or t-test was used for P value where appropriate. Δ means the difference from baseline level. Abbreviations:
FPG: Fasting Plasma Glucose; PPG: Postprandial Plasma Glucose; eGFR: Estimated Glomerular Filtration Rate; HDL: High Density Lipoprotein; LDL: Low Density
Lipoprotein; HOMA-B: Homeostatic Model Assessment of Beta Cell Function; HOMA-IR: Homeostatic Model Assessment of Insulin Resistance