Biomarker No. of MetS Components2 (Biomarker Mean ± SE) P3 0 1 2 3+ Metabolic Markers Total:HDL-C ratio 2.98 ± 0.10 3.62 ± 0.14 4.51 ± 0.13 5.25 ± 0.13 2.91x10-10 Apolipoprotein A1 (g/L) 1.57 ± 0.018 1.42 ± 0.018 1.32 ± 0.015 1.23 ± 0.018 2.22x10-8 Apolipoprotein B (g/L) 0.81 ± 0.027 0.86 ± 0.031 0.96 ± 0.032 1.03 ± 0.028 0.000047 HbA1c (%) 5.5 ± 0.1 5.6 ± 0.1 5.7 ± 0.1 5.8 ± 0.1 0.00073 Inflammatory Markers           C-reactive protein (mg/L) 1.40 ± 0.22 2.22 ± 0.23 3.04 ± 0.24 3.91 ± 0.40 2.69x10-8 Fibrinogen (g/L) 0.029 ± 0.001 0.031 ± 0.001 0.032 ± 0.001 0.032 ± 0.002 0.00036 Homocysteine (µmol/L) 7.78 ± 0.30 7.84 ± 0.29 7.96 ± 0.27 8.12 ± 0.43 0.435 1Measures were evaluated in non-diabetic subjects aged 16 to 79 years from the Canadian Health Measures Survey 2Means are adjusted for age, sex, smoking status, physical activity levels, use of cardiovascular related medication and ethnicity 3P for trend

Table 2: Plasma levels of cardiometabolic and inflammatory markers across the metabolic syndrome components1.