Transporter Gene (locus) Substrate specificity
Transport inhibitors GDM effect in human fetal endothelium GDM effect in CNS
hENT1 SLC29A1 (6p21.2-p21.1) Purine and pyrimidine
nucleosides
NBTI (<1 μM)
dipyridamole, dilazep
Decreased expression and activity in HUVEC and hPMEC* Decreased expression and activity in mouse fetal astrocytes**
hENT2 SLC29A2 (11q13) Purine and pyrimidine
nucleosides
NBTI (>1 μM) hypoxanthine Unaltered expression and activity in HUVEC
Decreased expression and activity in hPMEC*
Decreased expression and activity in mouse fetal astrocytes**
hENT3 SLC29A3 (10q22.2) Purine and pyrimidine
nucleosides, nucleobases,
monoamines
NBTI (>1 μM) dipyridamole nr nr
hENT4 SLC29A4 (7p22) Purine and serotonin NBTI (>10 μM)
uridine
nr nr
hENT: Human Equilibrative Nucleoside Transporter isoform; SLC: Solute Like Carriers; NBTI: Nitrobenzylthioinosine; HUVEC: Human Umbilical Vein Endothelial Cells; hPMEC: Human Placental Microvascular Endothelial Cells; nr: not reported. From data in references [42,143-146]. *C Salomón, F Westermeier, L Sobrevia, unpublished. *P Arroyo, L Sobrevia, unpublished.
Table 3: GDM effect on the human equilibrative nucleoside transporters family in fetal endothelium and CNS