NOS3
gene |
Disease |
|
T1DM |
T2DM |
Wild |
Rare |
Wild |
Rare |
4b/4a |
CF |
alleles
(%) |
87.50 |
12.50 |
75.81 |
24.19 |
DPN |
87.50 |
12.50 |
84.26 |
15.74 |
C |
85.06 |
14.94 |
86.27 |
13.73 |
CF/DPN |
P Value
(χ2) |
1.00 (0.00) |
0.17 (1.84) |
CF/C |
0.66 (0.20) |
0.09 (2.90) |
DPN/C |
0.001 (10.20) |
0.68 (0.17) |
rs1799983
(G894T) |
CF |
alleles
(%) |
44.23 |
55.77 |
69.35 |
30.65 |
DPN |
60.00 |
40.00 |
52.88 |
47.12 |
C |
55.19 |
44.81 |
61.11 |
38.89 |
CF/DPN |
P Value
(χ2) |
0.13 (2.25) |
0.037 (4.36) |
CF/C |
0.17 (1.87) |
0.28 (1.16) |
DPN/C |
0.59 (0.30) |
0.23 (1.46) |
NOS3, endothelial nitric oxide synthase; CF, free microvascular complications; DPN, diabetic neuropathy; C, combined diabetic microvascular complications (retinopathy, neuropathy, nephropathy). Significance (P Value) was 0.05 or less as accepted. Note, in T1DM the number of NOS3 4a carriers was significantly higher in C as compared with DPN subjects, suggesting that the rare allele was a risk factor for the prevalence of more than one microvascular disorder. In T2DM NOS3 894T allele might have an important role in the prevalence of DPN as the rare allele was significantly higher as compared with CF. |
