Gene

Variant

No association

DPN
risk

DPN protection

Reference

Type 1 diabetes

NOS1

CA repeats

P>0.05

 

 

38, 41

 

NOS2A

CCTTT repeats

 

 

Tendency

38, 41

 

 

NOS3

 

4a/4b

P>0.05

 

 

16, 38, 41

 

rs1799983
(G894T)

P>0.05

 

 

38, 41

 

 

P<0.05
for  894T

16, 46

Type 2 diabetes

NOS2A

AAAAT/AAAT

 

P<0.05
for AAAAT

 

40

NOS3

4a/4b

 

 

P<0.05*
for 4a

17

NOS3

rs1799983
(G894T)

 

P<0.05
for 894T

 

17


NOS1, neuronal nitric oxide synthase; NOS2A,inducible nitric oxide synthase; NOS3, endothelial  nitric oxide synthase; P, significance was 0.05 or less as accepted; * obese T2DM patients

Table 2: Gene polymorphisms of nitric oxide synthases in diabetic neuropathy, cumulative reports.