Animals |
Strains |
Model |
Regimen |
Age |
Sex |
Nociceptive behavorial test |
Reported pain symptoms (hyperalgesia/allodynia) |
Nerve Conduction |
References |
Rat |
ZDF |
Bio-Breeding Zuker Diabetic Rat (BBDZR) |
Rat chow |
8 months |
Male |
Plantar test |
Thermal hyperalgesia |
Decreased |
Kamiya H et al. 2005 |
Rat |
Wistar |
Goto-Kakizaki |
Rat chow |
7 to 32 weeks |
Male and female |
Tail-Flick |
Thermal hypoalgesia |
Not done |
Ueta K et al. 2005 |
Rat |
Wistar |
Goto-Kakizaki |
Rat chow |
6 weeks |
Male |
None |
None |
Decreased |
Kitahara Y et al. 2002 |
Rat |
Wistar |
Goto-Kakizaki |
Rat chow |
18 months |
Male |
None |
None |
Decreased |
Murakawa Y et al. 2002 |
Rat |
Wistar |
Goto-Kakizaki |
Rat chow |
10 weeks |
Male |
TailFlick |
Thermal hypoalgesia |
Not done |
Liepinsh E et al. 2009 |
Rat |
Long Evans |
Otsuka Long-Evans Tokushima Fatty (OLETF) |
30 % Sucrose in drinking water |
30 weeks |
Male |
None |
None |
Decreased |
Nakamura J et al. 1997 |
Rat |
Long Evans |
Otsuka Long-Evans Tokushima Fatty (OLETF) |
Sucrose feed |
2 months |
Male |
Tail Flickand Tail Pressure Test |
Mechanical and thermal hypoalgesia |
Decreased |
Kamenov Z et al. 2006 |
Rat |
SpragueDawley |
STZ-induced type II Diabetes* |
Standard rat diet supplemented with 10% sucrose, 10% lard, 2% cholesterol and 0,2% cholic acid + STZ 30 mg/kg |
4 weeks after induction of diabetes |
Male |
Radian Test |
Thermal hypoalgesia |
Decreased |
Xiu-ying Yang et al. 2011 |
Rat |
ZDF |
ZuckerDiabeticFatty |
Rat chow |
8 weeks |
Male |
von Frey hairs Test and Plantar Test |
Tactile allodynia |
Decreased |
Brussee V et al. 2008 |
Rat |
ZDF |
ZuckerDiabeticFatty |
Rat chow |
7 weeks |
Male |
von Frey hairs Test |
Tactile allodynia |
Not done |
Otto KJ et al. 2011 |
Rat |
ZDF |
ZuckerDiabeticFatty |
Rat chow |
6 to 10 weeks |
Male |
Randal-Selitto |
Mechanical hyperalgesia |
Not done |
Romanovsky D et al. 2008 |
Rat |
ZDF |
ZuckerDiabeticFatty |
Rat chow |
6 weeks after diagnostic of hyperglycemia |
Male |
von Frey and thermal stimulation |
Thermal hyperalgesia, Tactile allodynia. |
Decreased |
Li F et al. 2006 |
Rat |
ZDF |
ZuckerDiabeticFatty |
Rat chow |
15 weeks |
Male |
None |
None |
Decreased |
Shimoshige Y et al. 2000 |
Rat |
ZDF |
ZuckerDiabeticFatty |
Rat chow |
8 to 36 weeks |
Male and female |
Tail Flick, Randall-Selitto |
Thermal hypoalgesia followed by apersistent thermal hyperalgesia and tardive mechanical hyperalgesia. |
Not done |
Sugimoto K et al. 2008 |
*Developp by Srinivasan K et al. (PharmacolRes. 2005) |
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