Animals |
Strains |
Model |
Regimen |
Age |
Sex |
Nociceptive behavorial test |
Reported pain symptoms (hyperalgesia/allodynia) |
Nerve Conduction |
References |
Mice |
C57Bl6/J |
High Fructose Diet |
D12328, 10,5 kcal% fat, and D12330, 58kcal% fat with corn starch |
16 weeks of diet |
Male |
von Frey hairs test, Tail Flick |
Thermal and mechanical hypoalgesia, and tactile allodynia |
Decreased |
Watcho P et al. 2010 |
Mice |
C57Bl6/J |
High Fructose Diet |
D12328, 10,5 kcal% fat, and D12330, 58kcal% fat with corn starch |
16 weeks of diet |
Female |
von Frey hairs test, Tail Flick |
Thermal hypoalgesia, Tactile allodynia. |
Decreased |
Obrosova IG et al. 2007 |
Mice |
C57Bl6/J |
High Fructose Diet |
D12328, 10,5 kcal% fat, and D12330, 58kcal% fat with corn starch |
16 weeks of diet |
Female |
von Frey hairs test, Tail Flick |
Thermal hypoalgesia, Tactile allodynia. |
Decreased |
Stavniichuk R et al. 2010 |
Mice |
C57/BL6 |
high-fat (45% kcal %fat) diet |
45% kcal %fat diet D12451i |
34 weeks |
Male |
Radian test |
Thermal hypoalgesia |
Decreased |
Vincent AM 2009 |
Mice |
C57BLKS/J |
Leptin receptor-deficient db/db mice |
Micechow |
10-12 weeks |
Male |
Beam walk, Footprinting, Grid walk, Rotarod |
None |
Decreased |
Muller KA et al. 2009 |
Mice |
BKS.Cg-m+/+Leprdb/J |
Leptin receptor-deficient db/db mice |
Micechow |
24 weeks |
Male |
Hind paw withdrawal time and Tail Flick |
Thermal hypoalgesia |
Decreased |
Pande M et al. 2011 |
Mice |
C57BLKS |
Leptin receptor-deficient db/db mice |
Micechow |
? |
Male |
von Frey hairs test |
Mechanical hyperalgesia |
Not done |
Cheng HT et al. 2010 |
Mice |
C57BLKS |
Leptin receptor-deficient db/db mice |
Micechow |
10 weeks |
? |
von Frey hairs test |
Mechanical allodynia |
Not done |
Liao YH et al. 2010 |
Mice |
BKS.Cg-m+/+Leprdb/J |
Leptin receptor-deficient db/db mice |
Micechow |
9 to 16 weeks |
Male |
von Frey hairs test, Dynamic plantar aesthesiometer, Plantar test, Formalin |
Mechanical hyperalgesia, hypoesthesia in second phase of formalin test |
Not done |
Wright DE et al. 2007 |
Mice |
C57BLKS/J |
Leptin receptor-deficient db/db mice |
Micechow |
1 to 5 month |
Male |
von Frey hairs test |
Mechanicalhypersensitivity |
Not done |
Ren YS et al. 2012 |
Mice |
C57Bl6/J |
Leptin-deficient ob/ob mice |
Micechow |
8 weeks |
? |
von Frey hairs test, Radian test, Hot plate test (55°C) |
Thermal hypoalgesia, Tactile allodynia. |
Decreased |
Vareniuk I et al. 2007 |
Mice |
C57Bl6/J |
Leptin-deficient ob/ob mice |
Micechow |
6 weeks |
? |
von Frey hairs test, Radian test |
Thermal hypoalgesia, Tactile allodynia. |
Decreased |
Drel VR et al. 2006 |
Mice |
C57BL6 |
Leptin-deficient ob/ob mice and Leptin receptor-deficient db/db mice |
Micechow |
4 months |
Male and female |
None |
None |
Not done |
Nowicki M et al. 2012 |
Mice |
CD1 |
Stress-induced type 2 Diabetes |
Micechow |
30 days |
Male |
TailFlick |
Thermal hypoalgesia |
Not done |
Loizzo S et al. 2010 |
Mice |
ddY-SPF |
Tsumura, Suzuki, Obese Diabetes (TSOD) |
Micechow |
6 and 12 months |
Male |
Tail pressure test (Analgesymeter) |
Mechanical hyperalgesia |
Not done |
Iizuka S et al. 2005 |
