Table 1

		median normalisation						creatinine normalisation
		2011			2010			2011			2010
metabolite	nr.	Bonferroni p	log2FC	error	Bonferroni p	log2FC	error	Bonferroni p	log2FC	error	Bonferroni p	log2FC	error
2-hydroxyisobutyrate	28							5.08398E-05	0.60	0.02	0.001640099	0.62	0.11
2-methylglutarate	20							8.90977E-06	0.48	0.01
2-oxoisocaproate	24							0.026346487	0.65	0.03
3-methylglutarate					0.000217485	-0.35	0.05
Alanine	1	2.30443E-07	1.12	0.03	0.000189398	0.95	0.14	3.79254E-07	1.44	0.03	7.95791E-05	1.10	0.15
Alloisoleucine	4	2.87668E-05	0.66	0.02	0.048853951	0.23	0.06	1.01314E-05	0.97	0.03	0.029174508	0.38	0.09
Betaine	16	0.004415538	-0.24	0.01
Choline	10	0.041979148	0.37	0.02				0.000807888	0.68	0.03
Cis-aconitate	25							0.013382872	1.23	0.06
Creatinine	13	0.001866606	-0.31	0.01
Dimethylamine	11	0.004785616	-0.29	0.01
Ethanolamine*	12	0.000436376	-0.32	0.01	0.002733761	0.67	0.12				0.002348867	0.82	0.15
Glutamine	23							0.001535616	0.59	0.02
Glycylproline	26							0.023401534	0.59	0.03
Hippurate	8	8.7678E-06	-0.63	0.02	7.96473E-05	-0.69	0.09	0.030689263	-0.32	0.02	0.001228771	-0.57	0.10
Isoleucine	6	3.42392E-05	0.80	0.02	0.008592067	0.34	0.07	8.13268E-07	1.11	0.03	0.008068433	0.49	0.10
Lactate	9	0.010369908	0.54	0.03				3.76008E-05	0.85	0.03	0.012303742	0.72	0.15
Leucine	3	2.21915E-07	1.15	0.03				1.68387E-07	1.46	0.03
Malonate											0.02242326	0.46	0.11
Methionine	22							0.029274138	0.62	0.03
Methylamine	18	0.002108651	-0.31	0.01
Methylguanidine	19	6.26868E-05	-0.35	0.01
N.N-dimethylglycine	21							0.044691484	0.27	0.02
N-acetylglutamate	17	0.000797992	-0.29	0.01
N-isovaleroglycine	7	0.040530385	0.41	0.02	0.031514826	0.26	0.06	0.000924383	0.72	0.03	0.034029713	0.41	0.10
O-acetylcarnitine					0.020783386	0.29	0.06				0.012390392	0.42	0.09
Suberate	14	0.04311869	-0.68	0.04	0.00464694	-0.36	0.07
Succinate	27				0.012021138	0.49	0.11	0.007825682	0.57	0.03	0.003094892	0.64	0.12
Trimethylamine-N-oxide	15	0.00853877	-0.22	0.01
Tyrosine	5							0.001960367	0.59	0.02
Valine	2	3.81256E-08	1.19	0.02	1.00024E-06	0.79	0.08	2.91723E-08	1.50	0.03	5.19345E-06	0.94	0.11

Table 1: Metabolites detected by NMR that changed following glucose infusion, normalised to either the sample median or corresponding creatinine concentration. Only metabolites with a p-value below 0.05 after Bonferroni correction (Bonferroni p) were accepted and no restriction was applied with regard to fold change (log2FC = log2 fold change, with baseline measurements as reference). Empty spaces represent detected, but non-(significantly) changing metabolites. *=inconsistent result for this metabolite.