Criteria GK T2DN Early increase in GFR (hyperfiltration) + + + + >10-fold increase in albuminuria + + + + Mesangial matrix expansion + + + + Thickening of glomerular basement membrane + + + + Renal interstitial fibrosis + + + + Arteriolar hyalinosis NO YES Nodular glomerular lesions NO YES 50% decline in renal function NO YES These criteria were set forth by the AMDCC for a rodent model of diabetic nephropathy +indicates the severity within the individual criteria as compared to nondiabetic rat strains

Table 1: Criteria for diabetic nephropathy in GK and T2DN rats.