Carbendazim (mg /kg/day)

0

150

300

600

Number of females

30

30

30

30

Number of pregnant (%)a

27 (90)

26 (87)

27 (90)

28 (93)

No. of litters

27

26

27

28

No. of implantation/litter

10.55 ± 0.2

10.15 ± 0.5

10.00 ± 0.4

10.11 ± 0.2

% post implantation lossb

0.4 ± 6

0.4 ± 6

0.4 ± 8

0.2 ± 8

Live fetuses/litter (%)c

10.51± 4 (99.6)

10.11 ± 5 (99.6)

9.96 ± 4 (99.6)

10.09 ± 6 (98.6)

Dead fetuses/litter (%)c

0

0

0

0

Early resorptions/litter (%)c

0.04 ± 4 (0.4)

0.04 ± 4 (0.4)

0.04 ± 5 (0.4)

0.02 ± 6 (0.2)

Late resorptions/litter (%)c

0

0

0

0

Litters with resorption (%)

1 (4)

1 (4)

1 (4)

1 (4)

Litters totally resorbed (%)

0

0

0

0

Sex ratio (M/F)/litter

1.03± 2

1.10±1

1.08± 2

1.07± 2

Fetal body weight (g)/litter

1.98± 0.1

0.97± 0.1**

0.99± 0.3**

0.88± 0.5**

aNumber of females detected as being pregnant by visual inspection of the uterus/total number of females mated with males × 100. Sodium sulfide staining was carried out on all uteri without gross evidence of pregnancy but did not disclose resorption sites in any of the evaluated dams
b[(No. of implants–No. live fetuses)/No. of implants] × 100
cPercent of implantations
Table 4: Developmental toxicity in mice fetuses after exposure to metalaxyl on Gds 6–15.