Features

Tamoxifen

Letrozole

Anastrozole

Flutamide

Chemical structure

Physical property [8]

log Kow: 6.3, solubility: 17 mg/L

log Kow: 2.2, solubility: 102 mg/L

log Kow: 2.4, solubility: 500 mg/L

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Environmental occurrence [73, 74]

hospital effluent: 8.2 ng/L, surface water: < 5.8 ng/L

hospital effluent: 2.4 ng/L

hospital effluent: 3.7 ng/L

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Ecotoxicology [2, 75-80]

EC50 > 5 µg/L in various assays

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minimal effective concentration > 1 µg/L in various assays

Treatment strategy

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Table 9: Summary of endocrine therapy.