Figure 1: Schema of mitochondrial ROS involved in gastric cancinogenesis. Cag A: Cytotoxin-associated antigen A; cag PAI: cag-pathogenicity island; GPx: Glutathione Peroxidase; H. pylori, Helicobacter pylori; Keap1: Kelch-like ECHassociated protein 1; MnSOD: Manganese Superoxide Dismutase; NOX: NADPH Oxidase; NF-κB: Nuclear Factor-κB; NO: Nitric Oxide; Nrf2: NF-E2 p45-related factor-2; 8-OHdG: 8-hydroxy-2’-deoxyguanosine; ROS: Reactive Oxygen Species; Vac A: Vacuolating Cytotoxin A.