| 
      (* p<0.05 compared with Placebo at    post-treatment, Chi-square test)
        |  | Placebo | IM |  
        |  | Pre-treatment | Post-treatment | Pre-treatment | Post-treatment |  
        | Ulcers | 0% | 21% | 0% | 21% |  
        | Mucosal breaks | 0% | 37% | 16% | 42% |  
        | Denuded areas | 5% | 58% | 5% | 26%* |  
        | Reddened folds | 11% | 42% | 5% | 10%* |  
        | Red spots | 58% | 95% | 63% | 90% |  |