HMGB1(%)
characteristics n Low expression High exprssion P
gender
Male 24 15(62.50) 9(37.50)  
Female 11 5(45.45) 6(54.55) 0.467
Age(years)
≥59 19 11(57.89) 8(42.11)  
<59 16 9(56.25) 7(43.75) 1
T classification
T2 20 15(75.00) 5(25.00)  
T3-4 15 5(33.33) 10(66.67) 0.019*
N classification
N0 29 19(65.52) 10(34.48)  
N1 6 1(16.67) 5(83.33) 0.064
M classification
M0 30 20(66.67) 10(33.33)  
M1 5 0(0.00) 5(100.00) 0.009*
Clinical stage
I-II 24 18(75.00) 6(25.00)  
III-IV 11 2(18.18) 9(81.82) 0.003*
Table 2: Correlation between the clinicopathological features and expression of HMGB1 protein *Statistically significant difference.