Univariate Analysis Pb Risk factor HR 95%CI Age(years)         ≥59vs<59 1.26 0.593 2.675 0.546 Gender         Males vs female 0.788 0.354 1.751 0.564 T classification         T2 vs T3-T4 1.745 0.81 3.758 0.162 N classification         N0 vs N1 2.149 0.783 5.9 0.166 M classification         M0 vs M1 3.257 1.079 9.828 0.064 Clinical stage         I-II vs III-IV 2.929 1.22 7.035 0.021* HMGB1 expression         Low vs high 2.533 1.138 5.639 0.026*

Table 3: Univariate analysis of cancer-related survival in the total populations* Statistically significant difference.a. P of univariate analyses were determined by Cox regression analysis. b. HMGB1 expression was categorized according to the ration and the average intensity of positive-staining tumor cells into low expression (i.e., a final staining score of 7), high expression (i.e., a final staining score of ≥ 7).