Multivariate Analysis Pb Risk factor HR 95%CI Age(years)         ≥59vs＜59 1.338 0.546 3.281 0.524 Gender         Males vs female 0.798 0.326 1.954 0.622 T classification         T2vs T3-T4 1.414 0.539 3.71 0.482 N classification         N0vs N1 1.025 0.174 6.028 0.978 M classification         M0vs M1 1.445 0.217 9.619 0.704 Clinical stage         I-II vs III-IV 1.964 0.287 13.448 0.492 HMGB1 expression         Low vs high 1.46 0.442 4.819 0.535

Table 4: Multivariate analysis of cancer-related survival in the total populationsa. P of multivariate analyses were determined by Cox regression analysis. b. HMGB1 expression was categorized according to the ration and the average intensity of positive-staining tumor cells into low expression (i.e., a final staining score of 7), high expression (i.e., a final staining score of ≥ 7).