Authors Ethnic origin Cancer type Copy number changesOrdered by the exons of CDH1 Oliveria et al. Southern European HDGC Deletion of 5'-UTR-exon 1 Oliveria et al. Northern European HDGC Deletion of exon 1-2 Oliveria et al. Canadian HDGC Deletion of exon 1-2 Oliveria et al. Eastern European HDGC Deletion of exon 1-2 Yamada H et al. Japanese HDGC Deletion exon 3 Benusiglio et al. French LBC Deletion exon 3 Yamada M et al. Japanese HDGC Deletion of exon 7-16 Sugimoto et al. Japanese Early-onset DGC Deletion of exon 11 Benusiglio et al. French HDGC Deletion of exon 11 Oliveria et al. Central European HDGC Deletion of exon 14-16 Oliveria et al. Central European HDGC Deletion of exon 16

Table 1: Summary of the cases with germline copy number change in CDH1 gene; HDGC: hereditary diffuse gastric cancer; DGC: diffuse gastric cancer; LBC: lobular breast carcinoma