Author (year) # Compl % Definition of complications Early mortality Early mortality in analysis +ve or –ve study Survival interval reported Outcome for group with no complications vs those with complications Hirai (1998) (9) 205 56% Minor and major Ns Yes +ve (p<0.01) 5 yr 42% vs 21%/20% Kinugasa (2004) (10) 118 50% Pulmonary 7% InH Both +ve (p=0.03) HR 2.4 5 yr 54% vs 33% Mariette (2004) (1) 386 36% Prolonged hosp stay 4% InH Yes -ve (p=0.33) ns ns Rizk (2004) (5) 510 27% Technical 6% InH Yes +ve (p<0.001) HR 1.4 1 yr 3 yr 82% vs 58% 48% vs 31% Ancona (2006) (12) 522 16% Surgical 1% InH Yes -ve (p=0.90) ns ns Ferri (2006) (16) 434 23% Technical 5% InH Both -ve (p=0.35) Median 19 vs 14 months Lerut (2009) (18) 138 70% Clavien grade 1-5 1% 90d Yes +ve (p=0.01) HR 4.5 3 yr 62% vs 33% Takeuchi (2009) (7) 40 ns Ns 5% InH No -ve ns ns An (2012) (19) 123 29% Clavien grade 1-5 2% InH Yes +ve (p=0.004) HR 2.7 3 yr 57% vs 27% Carrott (2012) (30) 285 50% Accordion grade 1-5 1% InH Yes +ve (p=0.03) Median 1954 vs 1596 days D’Annoville (2012) (20) 405 56% Clavien grade 1-4 11% InH 16% 90d Both -ve (p=0.75/p=0.90) 5 yr 38% vs 47%/55% Nagasako (2012) (21) 400 9% Anastomotic 1% InH Yes +ve (p=0.009) HR  4.4 5 yr 94% vs 81% Rutegard (2012) (11) 616 23% Surgical 8% 90d Both -ve on univariate, +ve on multivariate HR 1.3 Median 24 vs 23 months

Compl = complication, hosp = hospital, HR = hazard ratio, InH = in hospital, 30d = 30 day mortality, 90d = 90 day mortality, +ve = statistically positive findings, -ve = statistically negative findings, ns = not stated

Table 2: Summary of literature reporting influence of postoperative complications on longterm survival after esophagogastric resection