Parameter Odds ratio SE 95% CI p value AFP >10ng/ml 1.1 0.01 1.0-1.1 <0.01 Male gender 0.67 0.08 0.53-0.85 0.001 Grade of necro-inflammation (A≥2) 0.47 0.06 0.37-0.59 <0.01 Stage of fibrosis (≥ F2) 1.5 0.18 1.2-1.9 0.001 HCV viral load ( >600 IU/ml) 1.7 0.21 1.3-2.2 <0.01 ALT( >40 IU/L) 1.0 0.0 0.99-0.99 0.01 AST (>40 IU/l) 1.0 0.0 0.99-0.99 0.01

Table 1: Multivariate Logistic regression analysis for baseline factors associated with failure of treatment (no SVR). AST:aspartate aminotransferase; ALT: alanine aminotransferase; AFP: alpha fetoprotein; n: number. Data expressed as mean ± SD.