Sustained DAI and Histology efficacy Data (EE population) Sustained clinical response Placebo DIMS0150 P value wk1 and wk4 0/11 6/19 (32) 0.06 wk1, wk4 and wk12 0/8 5/16 (31) 0.13 wk1, wk4, wk12 and wk24 0/6 3/13 (23) 0.29 Sustained clinical remission   wk1 and wk4 0/11 2/19 (11) 0.53 wk1, wk4 and wk12 0/8 2/16 (12.5) 0.54 wk1, wk4, wk12 and wk24 0/6 n.d.*   Sustained histological response       wk4 and wk12 0/8 (0) 3/16(19) 0.2 Sustained histological remission       wk4 and wk12  0/8 (0) 3/16 (19) 0.2

Table 2B: Sustained response and remission rates upon DIMS0150 treatment. Summary of the histological results following treatment with DIMS0150 or placebo at the times indicated given both as single time observations and as sustained time periods as indicated. (EE) population is defined by patients completing a scheduled visit. Sustained is defined as an effect duration that is equal to or greater than 2 consecutive scheduled visits. P-values calculated with Fisher’s Exact Test. * No wk24 data of patients with sustained response available.