Prenatal testosterone Colleteral cancer   ♂ ♀   Interaction Testosterone     - Incidence Estrogen     - Progression Fgfr2 + Ø + Differentiation Sox9 + Ø + Primary tumors Col4a2 + Ø + Weak evidence Col12a1 + Ø - Microsattelite instability Bmp6 - Ø - Progression Smad3 - Ø - Progression Wnt5a - Ø - Metastasis Runx2 - Ø - Incidence Mmp9 - Ø + Incidence Col6a2 Ø + + Incidence Fgf3 Ø - + Progression Msx1 Ø - + Metastasis Igfbp5 - - + Incidence

Table 1: Correlation between gene expression, prenatal testosterone and colorectal cancer in men and women. + - Positive correlation; - - Negative correlation; Ø – No known correlation; - Males; - Females; CRC Colorectal cancer.