12 months 24 months 36 months p-value YMDD motif mutation 0.292* IFN-LdT 1.92 5.97 13.1   LdT 4.55 10.01 22.73

Table 3: Cumulative Probability of LdT-resistant Mutation During LdT Treatment. Data are presented in percent. YMDD, tyrosinemethionine- aspartate-aspartate; IFN, interferon. *Log-rank (Mantelcox) chi square test.