Figure 1: Design of virosome vaccine made by influenza HANA proteins, B30-MDP and choresterol (A). The C-terminal portion of HA and the N-terminal peptide of neuraminidase molecules are expected to be inserted between parallel fatty acid branch of B30- MDP (A). The resultant liposome was confirmed by electron microscopic examination (B). As a result, a typical liposome covered with HA and NA spikes were observed, showing about 100 nm particles in diameter. Numbers of surface glycoprotein surface of liposome were certainly few when compared with that of VLP produced in silkworms.