Authors n IPC used Mean PCI Mean No. of Liver Lesions Median follow-up(months) Median over all survival (months) Median disease-frees urvival (months) Survival rates (%) Morbidity n(%)* Mortality n(%)*
Alzahranietal. (current study-unpublished data) 78 HIPEC: Oxaliplatin 350mg/m2 500mL of 5% dextrose,42°C,30 minutes. Mitomycin (12.5mg/m2),42ºC, 3L,30-90 minutes.EPIC:1L650-800 mg/m25-FUin1L1-5 days (pre02/10). 12.7 2.7 21.8 32.8 13.5 A:1,3,5 year: 95,62 and 31 B:1,3,5 year: 74,33 and 18 27(34.6) 1(1.3)
Ungetal. 36 HIPEC: Mitomycin (12.5mg/m2)in 42ºC 3L peritoneal dialysis fluid,30-90 minutes. EPIC:1L650-800 mg/m2 5-FUin1L peritoneal dialysis fluid,1-5days 7.0 2.3 21.8 24.4 8.5 1,3,5 year: 74, 33 and 18 14(39) 1(3)
Maggiori etal. [22] 37 11 (median) 2 (median) 36 (mean) 32 9 3 and 5 year:40 and 26 19(51) 3(8)
Chua etal. [23]** 16(55 total) AsUngetal. 8.0 19 2year:65% 17(31)* 0
Kianmanesh etal.[24]*** 16(43 total) HIPEC:6 Lmitomycin 120 mg and 6L 200mg/m2 for 30-90minutes 36 17(39)* 1(2)*
Elias etal.[25] 24 Various 8.6 4.4 27.8 (mean) 30-36 18-24 2,3,5 year:61.3,41.5 and 26.5 14(58) 1(4)
MEDIAN (RANGE) [26] 8.6(7-12.7) 2.5(2-4.4) 21.8(19-36) 24.4-36 8.5-24 5-year: 26.25 (18-31) 35(31-58) 1(0-8)
Table 3: Systematic Review of Retrospective Studies of Patients Undergoing Liver Resection with CRS/IPC. *Presented as percentage of all included patients** Of 16 patients with liver metastases, 10 patients had synchronous liver resection, 2 had cryotherapy and 4 had both. ***The timing of liver metastectomy in this study varied – between pre-operative, intra- and post-operative. “—‘’ denotes “unstated” or not applicable.