Figure 3: Mechanism involved in the secretion and regulation of H+ ions by H+K+ATPase pump. Vagus nerve provide signal with the help of muscarinic receptors which further stimulates Histamine releasing cells i.e enterochromaffin cells. Acetylcholine (Ach) works on acetylcholine receptors and lead to H+ ions release. Gastrin releasing cells release gastrin which work on gastrin receptors which further aid the process. Somatostatin releasing cells inhibits the histamine and gastrin releasing cells and thus regulates the secretion [11,12].