| |
Symptoms prior to SBI |
Therapeutics prior to SBI |
Other therapeutics while on SBI |
Initial response to SBI |
Long-term use of SBI and results |
| Patient #1
Ischemic Colitis
56-year-old Caucasian female |
5-10 loose stools daily with abdominal cramps, tenesmus, rectal urgency and intermittent fecal incontinence |
Anti-cholinergics, anti-diarrheals, antibiotics (metronidazole and rifaximin), dairy-free, gluten-free |
None |
After 4 weeks of SBI 5 g QD, patient reported satisfactory management of symptoms with 1-3 semi-formed stools per day with resolution of fecal incontinence. |
Advised to continue on SBI 2.5 g QD indefinitely. Decreased SBI to 2.5 g QD due to complaints of abdominal cramps. After a year on SBI 2.5 g QD, colonoscopy was unremarkable. |
| Patient #2
Pan-Ulcerative Colitis
26-year-old male |
Repeated flares of 5-10 bloody loose stools with tenesmus and cramping |
Oral and rectal mesalamine, antibiotics (ciprofloxin and metronidazole), probiotics, oral steroids, adalimumab |
Adalimumab, oral mesalamine, oral steroids (for the first 8 weeks) |
After 8 weeks, patient reported significant satisfaction with 1-2 normally formed stools per day and reported no other symptomology. He was completely removed from oral steroids. |
Advised to continue on SBI 5 g QD indefinitely while still on adalimumab and oral mesalamine. After a year with no flares while on all three therapies and no need for steroids, colonoscopy illustrated quiescent colitis with no active inflammation. |