Figure 1: Schematic of the possible CGRP mechanisms in diabetes resulting in delayed gastric emptying/gastroparesis when compared to a healthy state. In a healthy state, CGRP synthesis and receptors are increased. This increase of CGRP leads to normal muscular innervation and circulation. Somatostatin and gastric acid secretion are released at normal rates, and gastric motility and emptying are normal. As a result of increased insulin resistance, a healthy person can become diabetic. In diabetic states, CGRP levels decrease, resulting in decreased muscular relaxation and circulation. Somatostatin release and gastric sectretions decrease, resulting in abnormal gastric motility or gastroparesis.