Figure 1: Liver histology. Panel A depicts an H&E stained liver section (200X) demonstrating a dense portal inflammatory infiltrate comprised predominantly of lymphocytes with scattered plasma cells and marked interface activity. Significant lobular inflammation with focal necrosis also is noted. Immunohistochemical staining reveals infiltrates to be comprised predominantly of CD3+ T-cells (Panel B; 200X), with scattered CD20+ large B-cells (Panel C; 200X) and an abundance of CD68+ histiocytes (Panel D; 400X).