Comorbidities, n (%) All patients n=180 Without perforation n=159 With perforation n=21 P value                   IHD 44 (24.4 ) 38 (23.9 ) 6 (28.6) 0.600                 COPD 9 (5.0) 8 (5.0) 1 (4.8) 1.000                 Other* 46 (25.6) 41 (25.8) 5 (23.8) 1.000 Cholelithiasis 99 (55 0) 90 (56.6) 9 (42.9) 0.252 Cholecystectomy 55 (36 0) 50 (31.4) 5 (23.8) 0.617 Previous ERCP 39 (21.7) 34 (21.4) 5 (23.8) 0.782 Previous papillotomy 24 (13.3) 22 (13.8) 2 (9.5) 0.743

Table 2: Patient characteristics, IHD, ischemic heart disease; COPD, chronic obstructive pulmonary disease, *Diabetes mellitus, chronic renal failure, malignancy.