Number of tumors Patients/percent of cohort Size range [cm] Mean [cm] Median [cm] std. deviation [cm] 1 2147 (51.9%) 1-27.7 4.9 3.2 4.1 2 575 (13.9%) 1-22.2 4.4 3.3 3.3 3 178 (4.3%) 1-15 3.9 3.0 2.5 >3 1239 (30%) 0.9 – 26.0 7.9 8.5 4.3

Table 2: Reference profile ID and coefficient in the classification logistic regression model.