Baseline

4 week

12 week

24 week

Weight Parameters (SD)

Absolute Weight

120.6 (±23)

111.6 (±19.8)*

105.9 (±19.9)*

106.6 (19.6)*

BMI (kg/m²)

45 (± 7.3)

41.7 (±6.3)*

39.6 (±6.4)*

39.6 (±6.1)*

% EWL

-

14.8% (7.7)

20% (±7.7)^¶

22.2% (±9.7)^¶

Waist (cm)

133.7 (±16.5)

-

123.7 (±14.2)*

122.5 (±13.8)*

Glucose Parameters (SD)

Glucose

171.8 (±55.4)

138.8 (±39.9)*

146.4 (±59.1)*

141.5 (±44.6)*

HbA1c

8.8 (±1.6)

7.8 (±1.3)*

7.0 (±1.2)*

7.3 (±1.6)*

Insulin

21.8 (±15.3)

18.9 (±17.9)^§

15.1 (±12.9)*

17.6 (±10.2)^§

c- peptide

7 (±8.7)

4.7 (±2.0)^§

3.8 (±1.6)*

4.6 (±1.5)^§