Figure 3: Changes in microRNA profile and miR-222 expression after altering the levels of cellular polyamines. (A) Changes of global miRNA profile (top) as measured by miRNA array and the levels of miR-222 (bottom) as examined by Q-PCR analysis after polyamine depletion by treatment with DFMO. (B) Changes of global miRNA profile (top) and miR-222 levels (bottom) in ODC-IECs after increasing polyamine levels by ectopic ODC overexpression.