Site of Action Gene Promoter Region Anomaly         Serotonin transporter SLC6A4 5-HTTPLR SSRI-efficacy         P-Glycoprotein ABCB1 Upstream/downstream promoters ABC-transporter1         CRH-receptor of HPA axis2 CRHR1 Luciferase reporter plasmid Suicidality         5-HT2A receptor HTR2A -1438G/A (rs6311) Overdensity         Glucocorticoid receptor NR3C1 Luciferase reporter plasmid Stress adaptation         BDNF3 neurotrophin BDNF Multiple promoters AD-enhanced plasticity         AD-drug action MAGI2, DTWD1. WDFY4, and CHL1 Multiple promoters Symptom-exacerbation 1Transportation of a wide variety of substrates across extra- and intracellular membranes 2Corticotrophin-releasing hormone (CRH) of the hypothalamic-pituitary-adrenal axis (HPA) 3Brain derived neurotrophic factor (BDNF)

Table 1: The pharmacogenetics of certain genes associated with the pathophysiology or efficacy, metabolism, or availability of pharmacotherapeutic agents in mood disorders.