a. The dynamics and plasticity orchestrated by PRC/Mes-2. WT: wild type
b. Scheme of relationship of the mammalian Mi-2/NuRD-Myb-Muv/dREAM and PcG complex.
This simplified model focuses on the sequential action of the mammalian Mi-2/ NuRD-Myb-Muv/dREAM and PcG complex in cell division, though it is likely to be context-dependent. Each individual component may have other unique functions. Components of the Mi-2/NuRD complex, p53, dREAM, myb, and pRb are involved in mitotic exit, promoting differentiation. Particularly, pRb is essential for cell cycle exit and the differentiation of multi-/pluri-/bi-potent cells and is also uniquely required to maintain arrest in them. pRb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 lysine 27 (H3K27) on cell cycle genes, which require the polycomb complex (PcG) for terminal differentiation
Dashed line: gene expression level, arrowhead: the activation Dash: the repression
