| Major Criteria |
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■ Multiple (>2) basal cell carcinomas at any age or one basal cell carcinoma less than 30 years or >10 basal cell naevi |
|
■ Histologically proven odontogenic keratocyst or a polyostotic bone cyst
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■ Palmar or plantar pits (3 or more)
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■ Ectopic calcification: lamellar or early (<20 years) calcification of the falx cerebri
|
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■ Family history of Gorlin's syndrome
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| Minor Criteria |
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■ Congenital skeletal defects: bifid, fused, splayed, or missing rib, or bifid, wedged, or fused vertebra
|
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■ Large head with occipitofrontal circumference >97th percentile, with frontal bossing
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■ Cardiac or ovarian fibroma (benign tumour in heart or ovary)
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■ Medulloblastoma (a malignant brain tumour that usually arises in young children)
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■ Lymphomesenteric cysts (abdominal cysts full of lymph fluid)
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■ Congenital malformation: cleft lip and/or palate, polydactyly (extra fingers or toes), congenital eye defect such as cataract, microphthalmos (small eye) or coloboma (iris tumour)
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