Ic50 (NM) DRUG VEGFR1 VEGFR2 VEGFR3 RET BRAF OTHER TARGETS Sunitinib 2 9 17 41     Motesanib 2 3 6 59   PDGFR, cKIT Sorafenib   90 20 49 6   Vandetanib   40 110 100   EGFR Lenvatinib 22 4 5 35   PDGFR, FGFR Cabozantinib   0.035   5.2   MET, KIT

Table 3: Kinase inhibitor activities of drugs used in the treatment of advanced thyroid carcinomas.