1 Dry cough for at least 8 weeks without wheezing or dyspnoea
2 One or more findings suggesting an atopic predisposition† or induced sputum eosinophilia
3 No airway reversibility‡
4 Normal airway responsiveness
5 Increased cough sensitivity
6 No response to bronchodilator therapy
7 No abnormal findings on CXR
8 Normal pulmonary function
†Findings suggesting an atopic predisposition:
(i) Current or past history an allergic disorder other than asthma;
(ii) Peripheral blood eosinophilia;
(iii) Increased serum total IgE;
(iv)Positive for specific IgE; and
(v) Positive allergen intradermal test
‡Less than 10% increase in FEV1 with adequate dose of a bronchodilator
Helpful findings:
(i) Presence of eosinophils in tracheobronchial biopsy specimens;
(ii) Absence of eosinophils in BAL fluid; and
(iii) Relief of cough with histamine H1 antagonists and/or steroids.
Table 1: Diagnostic criteria for atopic cough (must fulfil all criteria 1–8)