1 |
A chronic cough in patients with no symptoms or objective evidence of variable airflow obstruction |
2 |
Normal airway hyper-responsiveness (provocation concentration of methacholin e producing a 20% decrease in forced expiratory volume in 1 minute (FEV1), PC 20 greater than 16 mg/mL). |
3 |
Sputum eosinophilia (An acceped upper cut-off level of greater than 3% nonsquamous sputum eosinophils) † |
†This is outside the 90th percentile for normal patients (1.1%). |