BMSCs Injection i.m. BMSCs injection i.v. NaCl injection i.m. HR time 0 208 ± 22 206 ± 23 205 ± 20 HR during ischemia 185 ± 18* 198 ± 21* 186 ± 24* HR time 1 212 ± 21 210 ± 20 208 ± 19 HR time 2 210 ± 19 207 ± 18 206 ± 15 HR time 3 209 ± 23 208 ± 20 203± 18 QTc interval time 0 420 ± 30 418 ±3 6 416 ± 25 QTc interval time 1 431 ±28** 309 ± 26** 436 ± 25** QTc interval time 2 428±19* 388±28* 421±34 QTc interval time 3 426±23 416±29 424±28

Table 1: Electrical parameters recorded in the days following the administration of BMSCs. The values in the table are the means of the number of events collected in 20 rabbits. HR: Heart Rate; QTc: Corrected (Interval QT corrected); T0 (before surgery); T1 (1 day after surgery); T2 (7 days after surgery); T3 (21 days after surgery); *P<0.05 vs T0 pre-ischemia, **P<0.001vs T0 pre-ischemia